Felitti et al. published this seminal work in the Journal of Preventive Medicine. This large-scale study linked Adverse Childhood Experiences (ACEs) to an increased risk of future adult health risks. The authors considered seven categories of (ACEs): psychological, physical, or sexual abuse, violence against mother; or living with household members who were substance abusers, mentally ill or suicidal, or ever imprisoned.
The authors found that the more adverse experiences an individual had, the increased likelihood of negative future health outcomes like alcoholism, drug abuse, cancer, and ischemic heart disease.