Perry et al. reviews the organization, function and development of the human brain in the context of brain-mediated responses to threat. These principles allow for an understanding of how a traumatized child is affected now and in the future.

Specifically, he discusses use-dependent organization of neural systems to explain development of dissociative (or disengagement from the external world) or hyperarousal (exaggerated reactivity) symptoms. Finally, Perry makes a case for the importance of early intervention and how it helps to lessen the intensity and severity of the response to trauma.

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